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7,500 +

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54,000

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*based on average data in the last 12 months

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Publication Updates

12 Mar

Martindale March 2019 Update

This update contains 13 new monographs and 22 existing monographs have been updated. Preparations have been updated for 5 countries.

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New monographs:

Baloxavir Marboxil: baloxavir is a polymerase acidic endonuclease inhibitor with antiviral activity. It is used as the marboxil salt to treat acute uncomplicated influenza A and B.
Binimetinib: an inhibitor of mitogen-activated extracellular kinase (MEK 1 and 2) that is used, with encorafenib, for the treatment of unresectable or metastatic melanoma.
Doravirine: is a non-nucleoside reverse transcriptase inhibitor, used with other antiretroviral agents, for the treatment of HIV-1 infection in treatment-naïve patients.
Encorafenib: is a BRAF kinase inhibitor that is used, with binimetinib, for unresectable or metastatic melanoma.
Fostamatinib: is a spleen tyrosine kinase inhibitor. It is used for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenia who have had an inadequate response to other therapies.
Fremanezumab: is a calcitonin gene-related peptide antagonist that is used for the prevention of migraine.
Galcanezumab: is a calcitonin gene-related peptide antagonist that is used for the prevention of migraine.
Ivosidenib: is an isocitrate dehydrogenase-1 (IDH1) inhibitor used in the treatment of relapsed or refractory acute myeloid leukaemia with an IDH1 mutation.
Lanadelumab: is a monoclonal antibody that inhibits plasma kallikrein. It is used as prophylaxis to prevent hereditary angioedema attacks.
Omadacycline: is an aminomethylcycline antibacterial that is used for the treatment of community-acquired pneumonia and acute skin and skin structure infections.
Ravulizumab: is a C5 complement blocker that is used for the treatment of paroxysmal nocturnal haemoglobinuria.
Revefenacin: is a long-acting antimuscarinic that is used via inhalation in the treatment of chronic obstructive pulmonary disease.
Vonicog Alfa: is a recombinant von Willebrand factor that is used for the treatment and prevention of bleeding in patients with von Willebrand’s disease.

Notable revisions:

Cabozantinib: is used for the treatment of hepatocellular carcinoma and as a first-line option for renal cell carcinoma.
Chloroquine: updated guidance on screening for retinopathy, and caution regarding lowering of the seizure threshold.
Crisaborole: is a phosphodiesterase type-4 (PDE-4) inhibitor that is used for the topical treatment of mild to moderate atopic eczema.
Denosumab: can be used for bone loss following long-term glucocorticoid therapy and for the prevention of skeletal events associated with multiple myeloma.
Durvalumab: is used for non-small cell lung cancer in adults whose tumours express PD-L1 and whose disease has not progressed following platinum-based chemotherapy and radiation therapy.
Eslicarbazepine: can be used in children for the treatment of partial seizures, either as monotherapy or adjuvant therapy.
Hydroxychloroquine: updated dosing, guidance on screening for retinopathy, and caution regarding lowering of the seizure threshold.
Ipilimumab: is used for the treatment of melanoma, renal cell carcinoma, and microsatellite instability-high or mismatch repair deficient colorectal cancer. Immune-mediated adverse effects, including fatalities, have been reported.
Nivolumab: is used for the treatment of squamous cell carcinoma of the head and neck, advanced urothelial carcinoma, hepatocellular carcinoma, and metastatic colorectal cancer. Immune-mediated adverse effects, including fatalities, have been reported.
Pembrolizumab: is used for the treatment of classical Hodgkin’s lymphoma, urothelial carcinoma, B-cell lymphoma, gastric or gastro-oesophageal junction adenocarcinoma, and microsatellite instability-high or mismatch repair deficient solid tumours or colorectal cancer, and cervical cancer. Immune-mediated adverse effects, including fatalities, have been reported.
Pivmecillinam: updated dosing for acute uncomplicated cystitis in adults and treatment of urinary tract infections in children.
Tolvaptan: updated dosing when patient is at risk of too rapid correction of sodium. Precautions on liver function test monitoring, interactions with CYP3A4, and side effects also updated.
Valganciclovir Hydrochloride: can be used in children for CMV prophylaxis in those who have had a transplant from a CMV-positive donor.

Updated names, synonyms and codes; official standards; official preparations:

BP 2018
Ph Eur 9.4 and 9.5

Proprietary Preparations and Manufacturers updated for the following countries and regions:

BP 2018
Denmark
Finland
Netherlands
UK†
USA†

† Countries updated on an ongoing basis

11 Dec

Martindale December 2018 update

This update contains 14 new monographs and 18 existing monographs have been updated. Preparations have been updated for 6 countries.

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New monographs:

Angiotensin II and Angiotensin II Acetate: is a synthetic human angiotensin II that is used as a vasopressor in septic or other distributive shock.
Apalutamide: is a nonsteroidal anti-androgen that is used for the treatment of non-metastatic, castration-resistant prostate cancer.
Avatrombopag and Avatrombopag Maleate: is a thrombopoietin receptor agonist licensed to reduce bleeding risk in patients with chronic liver disease undergoing surgery.
Darvadstrocel: is an allogeneic expanded adipose-derived stem cell therapy. It is used for the treatment of fistulising Crohn’s disease.
Elagolix and Elagolix Sodium: is a gonadorelin antagonist. It is used for the management of moderate to severe pain associated with endometriosis.
Emicizumab: is a monoclonal antibody that acts as a factor VIII mimetic. It is used to prevent bleeding episodes in patients with haemophilia A who have developed factor VIII antibodies.
Eravacycline and Eravacycline Hydrochloride: is a tetracycline derivative that is used for the treatment of complicated intra-abdominal infections.
Latanoprostene bunod: is a synthetic analogue of dinoprost that is used topically in the treatment of glaucoma and ocular hypertension.
Padeliporfin and Padeliporfin Potassium: is a bacteriochlorophyll derivative that is used as a photosensitiser for the photodynamic therapy of prostate cancer.
Plazomicin and Plazomicin Sulfate: is a derivative of sisomicin that is used for the treatment of complicated urinary-tract infections, including pyelonephritis.
Sodium Zirconium Cyclosilicate: is a potassium binder that is used for the treatment of hyperkalaemia.
Tecovirimat: is an antiviral that inhibits the orthopoxvirus VP37 envelope wrapping protein that may be used for the treatment of smallpox in the event of an outbreak.
Tezacaftor: is a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector that is used in combination with ivacaftor in the treatment of cystic fibrosis.
Tildrakizumab: is a humanised monoclonal antibody that is an interleukin-23 antagonist and is used for the treatment of plaque psoriasis.

Notable revisions:

Adalimumab: is used for the treatment of uveitis in children and hidradentis suppurativa in patients 12 years and older.
Ataluren: is used in children from the age of 2 years old for the treatment of Duchenne muscular dystrophy (DMD).
Certolizumab pegol: is used for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
Daclizumab: it has been withdrawn worldwide for the treatment of multiple sclerosis because of the risk of serious inflammatory brain disorders.
Fosaprepitant: is used in children from the age of 6 months old for nausea and vomiting associated with chemotherapy.
Mogamulizumab: is used for the treatment of mycosis fungoides, Sezary syndrome, and cutaneous and peripheral T-cell lymphoma.
Rufinamide: is used in children from 1 year of age in the treatment of Lennox-Gastaut syndrome.
Tapentadol: can be used in children from 2 years of age for the management of moderate to severe pain.
Tiotropium Bromide: is used in children from 6 years of age for the treatment of asthma.

Updated names, synonyms and codes; official standards; official preparations:

USP41/USNF36.

Proprietary Preparations and Manufacturers updated for the following countries and regions:

Belgium
Czech Republic
Ireland
Norway
UK
USA

14 Sep

Martindale September 2018 update

This update contains 8 new monographs and 7 existing monographs have been updated. Preparations have been updated for 6 countries.

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New Monographs:

Abemaciclib: is a cyclin-dependent kinases 4 and 6 inhibitor used in the treatment of advanced or metastatic breast cancer.
Axicabtagene ciloleucel: is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy that is used for the treatment of relapsed or refractory large B-cell lymphoma.
Burosumab: is a monoclonal antibody that inhibits fibroblast growth factor 23 that is used for the treatment of X-linked hypophosphataemia.
Erenumab: is a human monoclonal antibody that inhibits the activity of calcitonin gene-related peptide and is used for the prevention of migraine.
Ibalizumab: is a post-attachment HIV-1 inhibitor used in the treatment of multidrug-resistant HIV infection.
Lutetium-177: is a radionuclide that is used to label medicinal products.
Lutetium (177Lu) oxodotreotide: is a radioconjugate that is used for the treatment of gastroenteropancreatic neuroendocrine tumours.
Tisagenlecleucel: is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy that is used for the treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukaemia in patients up to 25 years of age.

Notable revisions:

Dalbavancin: can be used in a single-dose regimen for the treatment of acute bacterial skin and skin structure infections.
Evolocumab: also licensed to reduce cardiovascular risk in established cardiovascular disease.
Tocilizumab: also licensed for giant cell arteritis and for chimeric antigen receptor (CAR) T-cell induced cytokine release syndrome.

Proprietary Preparations and Manufacturers updated for the following countries and regions:

Austria, China, South Africa, UAE, UK and USA. († Countries updated on an ongoing basis)

11 Jun

Martindale June 2018 update

This update contains 11 new monographs and 28 existing monographs have been updated. Preparations have been updated for 5 countries.

See details

New Monographs:

Bictegravir: is an HIV-integrase inhibitor used in the treatment of HIV infection.
Cerliponase alfa: is a recombinant enzyme used to slow the loss of motor function and language skills in symptomatic patients with late-infantile neuronal ceroid lipofuscinosis type 2.
Ertugliflozin: is a sodium-glucose co-transporter 2 inhibitor that is used for the treatment of type 2 diabetes mellitus.
Gusekumab: is an antibody that targets interleukin-23 and is used for the treatment of plaque psoriasis.
Letermovir: is a CMV DNA terminase complex inhibitor that is used for the prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic haematopoietic stem cell transplant.
Macimorelin: is a growth hormone stimulant used orally for the diagnosis of adult growth hormone deficiency.
Migalastat: is a stabiliser of the alpha galactosidase A enzyme that is used orally in the treatment of Fabry disease.
Naldemedine: is a peripherally-acting opioid antagonist used for the treatment of opioid-induced constipation in patients with chronic, non-cancer pain.
Ozenoxacin: is a quinolone antibacterial applied topically in the treatment of impetigo.
Semaglutide: is a glucagon-like peptide 1 receptor agonist used in the treatment of type 2 diabetes mellitus.
Voretigene neparvovec: is a gene therapy product used for treating biallelic RPE65 mutation-associated retinal dystrophy.

Notable revisions:

Asfotase alfa: also licensed for paediatric-onset hypophosphatasia. Adverse effects and precautions has been updated.
Canagliflozin: abstract on risk of amputation added.
Ceftriaxone Sodium: uses and administration has been updated.
Ceritinib: uses extended to include first-line treatment of metastatic non-small cell lung cancer.
Desmopressin: new abstract on administration added. Uses and administration has been updated.
Eculizumab: also licensed for use in myasthenia gravis.
Empagliflozin: also licensed to reduce the risk of cardiovascular death in patients with type 2 diabetes mellitus.
Interferon Alfa: also licensed for the treatment of hepatitis B in children. Adverse effects have been updated.
Metformin: diabetes mellitus abstract has been updated with information on use in the prevention of type 2 diabetes mellitus.
Methylthioninium Chloride: new record on incompatibility added and administration in children abstract has been updated.
Ocrelizumab: also licensed for the treatment of relapsing and primary progressive multiple sclerosis.
Ulipristal acetate: use for treating uterine fibroids restricted following reports of serious liver injury.

Updated names, synonyms and codes; official standards; official preparation: Ph Eur 9.3 and USP40/USNF35 Suppl 1 and 2.

Proprietary Preparations and Manufacturers updated for the following countries and regions: India, Philippines, UK†, USA†, Venezuela. († Countries updated on an ongoing basis)

13 Mar

Martindale March 2018 update

This update contains 3 new monographs and 5 existing monographs have been updated. Preparations have been updated for 5 countries.

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New monographs:

Acalabrutinib: is an inhibitor of Bruton’s tyrosine kinase used in mantle cell lymphoma.
Benralizumab: is an IL-5-alpha receptor antibody used as add-on maintenance treatment in severe eosinophilic asthma.
Netarsudil and Netarsudil Mesilate: is a Rho-kinase inhibitor used in the treatment of glaucoma and ocular hypertension.

Notable revisions:

Aliskiren Fumarate: also licensed for use in children. Interactions, reviews, and heart failure records have been updated.
Metformin Hydrochloride: licence extended for prevention of type 2 diabetes in high-risk patients. Administration in renal impairment abstract has been updated.
Sevelamer: can be used in children from 6 years of age.
Topiramate: uses and administration, adverse effects, and precautions records have been updated.
Tranexamic Acid: uses and administration updated, haemorrhagic disorders abstract has been updated.

Updated names, synonyms and codes; official standards; official preparations: Ph Eur 9.1, Ph Eur 9.2

Proprietary Preparations and Manufacturers updated for the following countries and regions: Argentina, Australia, Indonesia, UK†, USA†. († Countries updated on an ongoing basis)

12 Dec

Martindale December 2017 update

This update contains 9 new monographs and 7 existing monographs have been updated. Preparations have been updated for 5 countries.

See details

New monographs:

Cenegermin: is a recombinant human nerve growth factor that is used topically for the treatment of moderate or severe neurotrophic keratitis.
Copanlisib and Copanlisib Hydrochloride: is a phosphoinositide-3 kinase (PI3K) inhibitor that is licensed for the treatment of relapsed follicular lymphoma.
Enasidenib and Enasidenib Mesilate: is an inhibitor of isocitrate dehydrogenase-2 (IDH2) approved for the treatment of relapsed or refractory acute myeloid leukaemia with an IDH2 mutation.
Evogliptin: is a dipeptidylpeptidase-4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus.
Glecaprevir: is a NS3/4A protease inhibitor that is approved for the treatment of hepatitis C.
Niraparib and Niraparib Tosilate: is a PARP inhibitor that is licensed for the treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer.
Pibrentasvir: is a NS5A inhibitor that is used for the treatment of hepatitis C.
Sarilumab: is a human monoclonal antibody that targets the interleukin-6 receptor and is licensed for the treatment of moderate to severe active rheumatoid arthritis.
Voxilaprevir: is a NS3/4A protease inhibitor that is used for the treatment of hepatitis C.

Notable revisions:

Bicalutamide: adverse effects and precautions updated. Unlicensed dose for metastatic prostate cancer added. References updated.
Cladribine: an oral formulation is launched for the treatment of highly active relapsing multiple sclerosis.
Eribulin: is licensed for the treatment of liposarcoma.
Febuxostat: is licensed for the prevention and treatment of hyperuricaemia in patients undergoing chemotherapy for haematologic malignancies at intermediate to high risk of tumour lysis syndrome.
Ibrutinib: is licensed for use in marginal zone lymphoma and chronic graft-versus-host disease.
Ketamine Hydrochloride: use in obstetrics added. Pain and psychiatric disorders abstracts have been updated.
Palbociclib: is licensed for use with fulvestrant for endocrine-receptor positive, HER2-negative advanced or metastatic breast cancer that has progressed following prior endocrine therapy.

Updated names, synonyms and codes; official standards; official preparations: BP 2017

Proprietary Preparations and Manufacturers updated for the following countries and regions: Brazil, Greece, Malaysia, UK†, USA†. († Countries updated on an ongoing basis)

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