The Handbook on Injectable Drugs is the comprehensive, authoritative source on the compatibility and stability of injectable drugs.

It provides extensive, practical information on parenteral drugs commercially available internationally.

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Speed and accuracy: Supports rapid and accurate assessment of the compatibility of various solutions and additives with a given parenteral drug to maximise patient safety and enhance medication effectiveness.

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Breadth of content: Fully referenced information and tabulated results from primary research on parenteral drugs commercially available in the United States and other countries

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Key information: Storage requirements and general stability information, including pH, freezing, exposure to light, sorption and filtration characteristics, and repackaging information

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Clinically relevant: Detailed compatibility tables for each drug covering solution, additive, syringe, and Y-site

Publication Updates

11 Dec
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Handbook of Injectable Drugs December 2018 update

This update contains 5 new MedWatch alerts.

MedWatch Alerts Added: Fentanyl Citrate; Ketamine Hydrochloride; Neostigmine Methylsulfate; Norepinephrine Bitartrate; Succinylcholine Chloride

14 Sep
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Handbook of Injectable Drugs September 2018 update

This update includes 3 new monographs, 78 general revisions, 4 new MedWatch Alerts and 3 removed MedWatch Alerts. 

New monographs: Angiotensin II Acetate; Letermovir; Daunorubicin-Cytarabine Liposomal 

General Revisions: Busulfan; Omeprazole Sodium; Linezolid; Dalteparin Sodium; Caffeine Citrate; Cloxacillin Sodium; Epoprostenol Sodium; Mycophenolate Mofetil Hydrochloride; Amphotericin B Lipid Complex; Amphotericin B Liposomal; Daptomycin; Pantoprazole Sodium; Anidulafungin; Caspofungin Acetate; Tigecycline; Doripenem; Esomeprazole Sodium; Moxifloxacin Hydrochloride; Acetaminophen; Tranexamic Acid; Oritavancin Diphosphate; Rasburicase; Blinatumomab; Albumin Human; Amino Acids; Ampicillin Sodium; Cefazolin Sodium; Cytarabine; Daunorubicin Hydrochloride; Dexamethasone Sodium Phosphate; Fat Emulsion, Intravenous; Fentanyl Citrate; Folic Acid; Furosemide; Gentamicin Sulfate; Heparin Sodium; Hydrocortisone Sodium Succinate; Hydroxyzine Hydrochloride; Insulin; Magnesium Sulfate; Metronidazole; Morphine Sulfate; Naloxone Hydrochloride; Norepinephrine Bitartrate; Oxytocin; Potassium Chloride; Potassium Phosphates; Procainamide Hydrochloride; Trimethoprim-Sulfamethoxazole; Vancomycin Hydrochloride; Lorazepam; Nalbuphine Hydrochloride; Cyclosporine; Ceftriaxone Sodium; Aztreonam; Ceftazidime; Imipenem-Cilastatin Sodium; Midazolam Hydrochloride; Ampicillin Sodium-Sulbactam Sodium; Famotidine; Ganciclovir Sodium; Octreotide Acetate; Ciprofloxacin; Fluconazole; Immune Globulin Human; Amiodarone Hydrochloride; Diltiazem Hydrochloride; Filgrastim; Piperacillin Sodium-Tazobactam Sodium; Clonazepam; Tacrolimus; Appendix I; Cefepime Hydrochloride; Levofloxacin; Meropenem; Teicoplanin; ASHP’s Handbook on Injectable Drugs – References; ASHP’s Handbook on Injectable Drugs – Users Guide 

Medwatch Alerts Added: Naloxone Hydrochloride; Neostigmine Methylsulfate; Ampicillin Sodium-Sulbactam Sodium; Piperacillin Sodium-Tazobactam Sodium 

Medwatch Alerts Removed: Hydromorphone Hydrochloride; Methylprednisolone Sodium Succinate; Labetalol Hydrochloride 

10 Jul
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Handbook on Injectable Drugs July 2018 update

This update contains 3 new monographs, 1 new MedWatch alerts, 105 General revisions and 8 deleted MedWatch Alerts.

New monographs: Ferric Carboxymaltose, Rolapitant Hydrochloride, Meropenem-Vaborbactam

General Revisions: Gemcitabine Hydrochloride, Linezolid, Rocuronium Bromide, Azithromycin, Dexmedetomidine Hydrochloride, Dexrazoxane Hydrochloride, Eptifibatide, Daptomycin, Ertapenem Sodium, Palonosetron Hydrochloride, Pantoprazole Sodium, Pemetrexed Disodium, Anidulafungin, Caspofungin Acetate, Micafungin Sodium, Tigecycline, Voriconazole, Doripenem, Esomeprazole Sodium, Ceftaroline Fosamil, Tedizolid Phosphate, Ceftolozane Sulfate-Tazobactam Sodium, Ceftazidime-Avibactam Sodium, Isavuconazonium Sulfate, Levoleucovorin Calcium, Albumin Human, Amikacin Sulfate, Atropine Sulfate, Calcium Chloride, Calcium Gluconate, Cefazolin Sodium, Clindamycin Phosphate, Colistimethate Sodium, Dexamethasone Sodium Phosphate, Digoxin, Diphenhydramine Hydrochloride, Dobutamine Hydrochloride, Dopamine Hydrochloride, Doxycycline Hyclate, Epinephrine Hydrochloride, Fentanyl Citrate, Fluorouracil, Furosemide, Gentamicin Sulfate, Heparin Sodium, Hydrocortisone Sodium Succinate, Hydromorphone Hydrochloride, Insulin, Lidocaine Hydrochloride, Magnesium Sulfate, Mannitol, Meperidine Hydrochloride, Methadone Hydrochloride, Methylprednisolone Sodium Succinate, Metoclopramide Hydrochloride, Metronidazole, Morphine Sulfate, Naloxone Hydrochloride, Neostigmine Methylsulfate, Nitroglycerin, Norepinephrine Bitartrate, Penicillin G Potassium, Phenylephrine Hydrochloride, Phenytoin Sodium, Potassium Chloride, Potassium Phosphates, Sodium Bicarbonate, Sodium Phosphates, Tobramycin Sulfate, Vancomycin Hydrochloride, Lorazepam, Bumetanide, Cefuroxime Sodium, Labetalol Hydrochloride, Ceftriaxone Sodium, Aztreonam, Ceftazidime, Imipenem-Cilastatin Sodium, Ranitidine Hydrochloride, Vasopressin, Esmolol Hydrochloride, Midazolam Hydrochloride, Carboplatin, Famotidine, Ganciclovir Sodium, Mesna, Octreotide Acetate, Ondansetron Hydrochloride, Vecuronium Bromide, Ciprofloxacin, Amiodarone Hydrochloride, Epirubicin Hydrochloride, Milrinone Lactate, Thiotepa, Diltiazem Hydrochloride, Piperacillin Sodium-Tazobactam Sodium, Cefepime Hydrochloride, Enoxaparin Sodium, Levofloxacin, Nicardipine Hydrochloride, Cisatracurium Besylate, Fosphenytoin Sodium, Remifentanil Hydrochloride, ASHP’s Handbook on Injectable Drugs – References, ASHP’s Handbook on Injectable Drugs – Users Guide.

Medwatch Alerts Added: Sodium-Sulbactam

Medwatch Alerts Removed: Ropivacaine Hydrochloride, Ephedrine Sulfate, Glycopyrrolate, Oxytocin, Succinylcholine Chloride, Immune Globulin Human, Bupivacaine Hydrochloride, Adenosine

14 Mar
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Handbook on Injectable Drugs March 2018 update

This update contains 5 new monographs and 39 revised monographs, 22 new and 4 updated MedWatch alerts, and the References and Users Guide have also been updated.

New monographs: Azacitidine; Carbamazepine; Bacitracin; Delafloxacin Meglumine.

Revised monographs: Linezolid; Bivalirudin; Ertapenem Sodium; Tranexamic Acid; Clevidipine Butyrate; Amino Acids; Calcium Gluconate; Cefazolin Sodium; Colistimethate Sodium; Dobutamine Hydrochloride; Ephedrine Sulfate; Epinephrine Hydrochloride; Heparin Sodium; Hydromorphone Hydrochloride; Insulin; Iothalamate Meglumine; Nitroglycerin; Papaverine Hydrochloride; Potassium Chloride; Promethazine Hydrochloride; Propranolol Hydrochloride; Sodium Bicarbonate; Sodium Nitroprusside; Vancomycin Hydrochloride; Aztreonam; Ceftazidime; Imipenem-Cilastatin Sodium; Esmolol Hydrochloride; Cefotetan Disodium; Hetastarch in Sodium Chloride 0.9%; Amiodarone Hydrochloride; Milrinone Lactate; Metoprolol Tartrate; Paclitaxel; Piperacillin Sodium-Tazobactam Sodium; Etomidate; Propofol; Meropenem; Nicardipine Hydrochloride.

New MedAlerts: Linezolid; Rocuronium Bromide; Ropivacaine Hydrochloride; Pantoprazole Sodium; Albumin Human; Calcium Gluconate; Ephedrine Sulfate; Fentanyl Citrate; Glycopyrrolate; Hydromorphone Hydrochloride; Morphine Sulfate; Phenylephrine Hydrochloride; Potassium Chloride; Succinylcholine Chloride; Labetalol Hydrochloride; Midazolam Hydrochloride; Ampicillin Sodium-Sulbactam Sodium; Immune Globulin Human; Amiodarone Hydrochloride; Bupivacaine Hydrochloride; Levofloxacin; Adenosine.

Updated MedAlerts: Oxytocin; Sodium Chloride; Vancomycin Hydrochloride; Alteplase.

15 Nov
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Handbook on Injectable Drugs November 2017 update

This update contains 156 revised monographs, the References and Users Guide have also been updated.

Revised monographs: Clevidipine Butyrate; Levocarnitine; Docetaxel; Linezolid; Tirofiban Hydrochloride; Rocuronium Bromide; Valproate Sodium; Abciximab; Arsenic Trioxide; Azithromycin; Bivalirudin; Cloxacillin Sodium; Dexmedetomidine Hydrochloride; Eptifibatide; Fenoldopam Mesylate; Mycophenolate Mofetil Hydrochloride; Quinupristin-Dalfopristin; Reteplase; Acetylcysteine; Amphotericin B Lipid Complex; Amphotericin B Liposomal; Daptomycin; Ertapenem Sodium; Pantoprazole Sodium; Anidulafungin; Caspofungin Acetate; Micafungin Sodium; Nesiritide; Tigecycline; Voriconazole; Doripenem; Esomeprazole Sodium; Moxifloxacin Hydrochloride; Ceftaroline Fosamil; Tedizolid Phosphate; Ceftolozane sulfate-Tazobactam sodium; Isavuconazonium Sulfate; Cangrelor Tetrasodium; Albumin Human; Amikacin Sulfate; Amphotericin B; Ampicillin Sodium; Ascorbic Acid; Atropine Sulfate; Butorphanol Tartrate; Calcium Chloride; Calcium Gluconate; Cefazolin Sodium; Cefoxitin Sodium; Chlorpromazine Hydrochloride; Clindamycin Phosphate; Colistimethate Sodium; Cyanocobalamin; Dexamethasone Sodium Phosphate; Diazepam; Digoxin; Dimenhydrinate; Diphenhydramine Hydrochloride; Dobutamine Hydrochloride; Dopamine Hydrochloride; Doxycycline Hyclate; Droperidol; Ephedrine Sulfate; Epinephrine Hydrochloride; Erythromycin Lactobionate; Fentanyl Citrate; Furosemide; Gentamicin Sulfate; Haloperidol Lactate; Heparin Sodium; Hydralazine Hydrochloride; Hydrocortisone Sodium Succinate; Hydromorphone Hydrochloride; Insulin; Isoproterenol Hydrochloride; Ketamine Hydrochloride; Lidocaine Hydrochloride; Magnesium Sulfate; Mannitol; Meperidine Hydrochloride; Methylergonovine Maleate; Methylprednisolone Sodium Succinate; Metoclopramide Hydrochloride; Metronidazole; Morphine Sulfate; Multivitamins; Naloxone Hydrochloride; Nitroglycerin; Norepinephrine Bitartrate; Oxytocin; Penicillin G Potassium; Penicillin G Sodium; Phenylephrine Hydrochloride; Phenytoin Sodium; Potassium Chloride; Potassium Phosphates; Procainamide Hydrochloride; Prochlorperazine Edisylate; Promethazine Hydrochloride; Propranolol Hydrochloride; Sodium Bicarbonate; Sodium Nitroprusside; Sodium Phosphates; Tobramycin Sulfate; Trimethoprim-Sulfamethoxazole; Vancomycin Hydrochloride; Verapamil Hydrochloride; Cefotaxime Sodium; Lorazepam; Nalbuphine Hydrochloride; Acyclovir Sodium; Bumetanide; Cefuroxime Sodium; Cyclosporine; Labetalol Hydrochloride; Ceftriaxone Sodium; Aztreonam; Benztropine Mesylate; Ceftazidime; Imipenem-Cilastatin Sodium; Pentamidine Isethionate; Ranitidine Hydrochloride; Vasopressin; Esmolol Hydrochloride; Midazolam Hydrochloride; Theophylline; Ampicillin Sodium-Sulbactam Sodium; Famotidine; Mesna; Ticarcillin Disodium-Clavulanate Potassium; Alteplase; Enalaprilat; Octreotide Acetate; Ondansetron Hydrochloride; Vecuronium Bromide; Ciprofloxacin; Fluconazole; Immune Globulin Human; Amiodarone Hydrochloride; Milrinone Lactate; Metoprolol Tartrate; Diltiazem Hydrochloride; Filgrastim; Piperacillin Sodium-Tazobactam Sodium; Sufentanil Citrate; Tacrolimus; Alfentanil Hydrochloride; Propofol; Cefepime Hydrochloride; Levofloxacin; Meropenem; Nicardipine Hydrochloride; Salbutamol; Amphotericin B Cholesteryl Sulfate Complex; Cisatracurium Besylate; Fosphenytoin Sodium