The BNF for Children is the unrivalled guidance on prescribing, dispensing and administering medicines to children.

BNF for Children is the only child-focused drug formulary in the world that is both independent, and has rigorous, accredited content creation processes. It is trusted by health professionals worldwide as their primary source for minimising medication errors in paediatrics.

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Publication Updates

10 May
British National Formulary for Children logo
BNF for Children May 2022 Update

This update contains 5 significant changes and 1 dose change.

Significant Changes:
• Amiodarone hydrochloride (Cordarone X®): reminder of risks of treatment and need for patient monitoring and supervision [MHRA/CHM advice].
• COVID-19: updated guidance.
• Levetiracetam: addition of dosing for convulsive status epilepticus in children.
• Metformin hydrochloride: study shows no safety concerns in pregnancy [MHRA/CHM advice].
• Potassium permanganate: inadvertent oral administration of potassium permanganate [National Patient Safety Alert advice].

Dose change:
• Remdesivir [update to indications and dosing].

For further details on changes in the BNFC click on https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

11 Apr
British National Formulary for Children logo
BNF for Children April 2022 Update

This update contains 8 significant changes, 3 dose changes, 1 new preparation, and 1 deleted preparation.

Significant Changes:
• Chlorhexidine [primary therapeutic area changed to genito-urinary system, secondary therapeutic area changed to oropharynx].
• Chloroquine: increased risk of cardiovascular events when used with macrolide antibiotics; reminder of psychiatric reactions [MHRA/CHM advice].
• COVID-19 vaccines: updated guidance in-line with UK Health Security Agency recommendations.
• Hydroxychloroquine sulfate: increased risk of cardiovascular events when used with macrolide antibiotics; reminder of psychiatric reactions [MHRA/CHM advice].
• Immunisation schedule: updated guidance in-line with UK Health Security Agency recommendations.
• Ivacaftor: Ivacaftor, tezacaftor, elexacaftor (Kaftrio®▼) in combination with ivacaftor (Kalydeco®): risk of serious liver injury; updated advice on liver function testing [MHRA/CHM advice].
• Remdesivir: reporting to the UK COVID-19 Antivirals Pregnancy Registry [MHRA/CHM advice].
• Smoking cessation: updated guidance on management.

Dose Changes:
• Eltrombopag [addition of Southeast Asian ethnicity to dosing for treatment of chronic idiopathic thrombocytopenic purpura].
• Etanercept [update to dosing].
• Hepatitis B immunoglobulin [update to dosing in prophylaxis against hepatitis B infection from birth to 4 years old, and dosing in prevention of transmitted infection at birth].

New Preparation:
Vaxelis® [diphtheria with tetanus, pertussis, hepatitis B, poliomyelitis and haemophilus influenzae type b vaccine]

Deleted Preparation:
Synflorix® [pneumococcal polysaccharide conjugate vaccine (adsorbed)]

For further details on changes in the BNFC click on https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

08 Mar
British National Formulary for Children logo
BNF for Children March 2022 Update

This update contains 4 significant changes, 2 dose changes, and 1 new monograph.

Significant Changes:
• COVID-19: updated guidance.
• COVID-19 vaccines: updated guidance in-line with UK Health Security Agency recommendations.
• Miconazole: oral gel no longer licensed for treatment of intestinal candidiasis.
• Phosphate imbalance: updated guidance on the use of phosphate-binding agents.

Dose Changes:
• Eculizumab [update to children’s dosing].
• Heparin (unfractionated) [dose statement for maintenance of neonatal umbilical arterial catheter amended to reflect use in practice (route removed)].

New monograph:
Xevudy® [sotrovimab]

For further details on changes in the BNFC click on
https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

08 Feb
British National Formulary for Children logo
BNF for Children February 2022 Update

This update contains 6 significant changes, 3 new monographs, 1 deleted monograph and 1 deleted preparation.

Significant Changes:
• Aciclovir: important safety information added to highlight different approaches to calculating doses depending on the age of the child.
• Bacillus Calmette-Guérin vaccine: updated guidance for immunisation of neonates in-line with Public Health England/UK Health Security Agency recommendations.
• COVID-19 vaccine: update to age range of Pfizer/BioNTech vaccine (Comirnaty®) for immunisation against COVID-19.
• COVID-19 vaccines: updated guidance in-line with UK Health Security Agency recommendations.
• Immunisation schedule: updated guidance for immunisation of neonates in-line with Public Health England/UK Health Security Agency recommendations.
• Varicella-zoster vaccine: title changed to Varicella-zoster vaccines.

New Monographs:
Pradaxa® [dabigatran etexilate].
Xarelto® [rivaroxaban].
Xofluza® [baloxavir marboxil].

Deleted Monographs: Meningococcal group C vaccine.

Deleted Preparations: Cervarix® [human papillomavirus vaccines].

For further details on changes in the BNFC click on
https://www.medicinescomplete.com/#/content/bnfc/PHP107699

11 Jan
British National Formulary for Children logo
BNF for Children January 2022 Update

This update contains 6 significant changes, 1 dose change and 1 deleted preparation.

Significant Changes:
• Adrenaline/epinephrine auto-injectors: reminder for prescribers to support safe and effective use [MHRA/CHM advice].
• COVID-19: updated guidance.
• COVID-19 vaccines: updated guidance in-line with Public Health England/UK Health Security Agency recommendations.
• Malaria, prophylaxis: updated guidance in-line with Public Health England recommendations.
• Phenobarbital: updated information on the available oral solutions and advice from the RCPCH/NPPG can be found in the prescribing and dispensing section of the Phenobarbital monograph.
• Yellow fever vaccine, live (Stamaril®): new pre-vaccination checklist [MHRA/CHM advice].

Dose Changes:
• Adrenaline/epinephrine [update to dosing for acute anaphylaxis].

Deleted Preparations: Tacni® [tacrolimus].

For further details on changes in the BNFC click on https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

07 Dec
British National Formulary for Children logo
BNF for Children December 2021 Update

This update contains 8 significant changes, 2 dose changes, 1 classification change and 5 new monographs.

Significant Changes:
• Acne: updated guidance on management.
• Chloral hydrate, cloral betaine (Welldorm®): restriction of paediatric indication [MHRA/CHM advice].
• COVID-19 vaccine: title changed to COVID-19 vaccines.
• COVID-19 vaccines: updated guidance in-line with Public Health England/UK Health Security Agency recommendations.
• Nausea and labyrinth disorders: updated guidance on the management of nausea and vomiting during pregnancy.
• Rosacea and Acne: title changed to Rosacea.
• Tofacitinib (Xeljanz®): new measures to minimise risk of major adverse cardiovascular events and malignancies [MHRA/CHM advice].
• Type 1 diabetes: updated guidance on Recommended insulin regimens.

Dose Changes:
• Chloral hydrate [update to dosing information for short-term treatment of severe insomnia].
• Pyridostigmine bromide [update to dosing for myasthenia gravis in neonates and children].

Classification Changes:
• Minoxidil [primary classification changed to Potassium-channel openers].

New Monographs:
Acarizax® [house dust mite extract].
Cibinqo® [abrocitinib].
Koselugo® [selumetinib].
Orladeyo® [berotralstat].
Xeljanz® [tofacitinib].

For further details on changes in the BNFC click on
https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

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