The BNF for Children is the unrivalled guidance on prescribing, dispensing and administering medicines to children.

BNF for Children is the only child-focused drug formulary in the world that is both independent, and has rigorous, accredited content creation processes. It is trusted by health professionals worldwide as their primary source for minimising medication errors in paediatrics.

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Publication Updates

13 Sep
British National Formulary for Children logo
BNF for Children September 2022 Update

This update contains 7 significant changes, 3 dose changes, 5 new monographs, 1 new preparation, and 1 deleted preparation.

Significant Changes:
• Cystic fibrosis transmembrane conductance regulator modulators: update to hepatic impairment advice (see example in ivacaftor).
• Epilepsy: updated guidance on management.
• Hydrocortisone: addition of children’s dosing for adrenal crisis.
• Immunisation schedule: updated guidance for immunisation against influenza.
• Influenza vaccine: updated guidance for immunisation.
• Tezacaftor with ivacaftor and elexacaftor: name change to ivacaftor with tezacaftor and elexacaftor.
• Topiramate (Topamax®): start of safety review triggered by a study reporting an increased risk of neurodevelopmental disabilities in children with prenatal exposure [MHRA/CHM advice].

Dose Changes:
Briviact® (brivaracetam) [update to age range].
• Ivacaftor with tezacaftor and elexacaftor [update to age range].
• Tezacaftor with ivacaftor [update to age range].

New Monographs:
Aklief® [trifarotene].
• Magnesium citrate.
NovoThirteen® [factor XIII A-subunit (recombinant)].
Palforzia® [peanut protein].
Zepatier® [elbasvir with grazoprevir].

New Preparation:
Assicco® [glycopyrronium bromide].

Deleted Preparation:
• Codeine phosphate solution for injection.

For further details on changes in the BNFC click on https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

09 Aug
British National Formulary for Children logo
BNF for Children August 2022 Update

This update contains 2 significant changes, 1 dose change, 2 new monographs and 1 new preparation.

Significant Changes:
• Metformin hydrochloride: reduced vitamin B12 levels and new advice for monitoring patients at risk [MHRA/CHM advice].
• Type 1 diabetes: inclusion of continuous glucose monitoring in aims of treatment.

Dose Changes:
• Cyanocobalamin [update to indications and dose].

New Monographs:
Bylvay® [odevixibat].
• Colchicine.

New Preparations: Uxil® [dasatinib].

For further details on changes in the BNFC click on https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

12 Jul
British National Formulary for Children logo
BNF for Children July 2022 Update

This update contains 3 significant changes, 2 new monographs, and 1 new preparation.

Significant Changes:
• Anagrelide: risk of thrombosis, including cerebral infarction, if treatment discontinued abruptly [MHRA/CHM advice].
• Denosumab (Prolia®): should not be used in patients under 18 years due to the risk of serious hypercalcaemia [MHRA/CHM advice].
• Tacrolimus: updated pregnancy, breast-feeding and monitoring advice.

New Monographs:
Aubagio® [teriflunomide].
Ngenla® [somatrogon].

New Preparations:
Ogluo® [glucagon].

For further details on changes in the BNFC click on
https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

14 Jun
British National Formulary for Children logo
BNF for Children June 2022 Update

This update contains 6 significant changes, 3 dose changes, and 2 new monographs.

Significant Changes:
• Ear: updated guidance for the management of acute otitis media.
• Human papillomavirus vaccine: updated guidance in-line with UK Health Security Agency recommendations.
• Immunisation schedule: updated guidance for immunisation against human papillomavirus and influenza.
• Influenza vaccine: updated guidance in-line with UK Health Security Agency recommendations.
• Paediatric Steroid Treatment Card to support early recognition and treatment of adrenal crisis in children with adrenal insufficiency [British Society for Paediatric Endocrinology and Diabetes] (advice in alclometasone dipropionate; beclometasone dipropionate; benzyl benzoate with bismuth oxide, bismuth subgallate, hydrocortisone acetate, peru balsam and zinc oxide; betamethasone; budesonide; ciclesonide; cinchocaine hydrochloride with fluocortolone caproate and fluocortolone pivalate; cinchocaine with hydrocortisone; cinchocaine with prednisolone; ciprofloxacin with fluocinolone acetonide; clobetasol propionate; clobetasone butyrate; deflazacort; dexamethasone; diflucortolone valerate; fludrocortisone acetate; fludroxycortide; flumetasone pivalate with clioquinol; fluocinolone acetonide; fluocinonide; fluorometholone; fluticasone; gentamicin with hydrocortisone; hydrocortisone; hydrocortisone butyrate; hydrocortisone with lidocaine; loteprednol etabonate; methylprednisolone; mometasone furoate; prednisolone; triamcinolone acetonide; triamcinolone hexacetonide; see example in  dexamethasone).
• Pain, chronic: new guidance for management in children.

Dose Changes:
• Dexamethasone [update to dosing for COVID-19 requiring supplemental oxygen].
• Erythromycin [amended age range for otitis media and sore throat in children].
• Human papillomavirus vaccines [update to indications and dosing].

New Monographs:
Givlaari® [givosiran].
Rinvoq® [upadacitinib].

For further details on changes in the BNFC click on https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

10 May
British National Formulary for Children logo
BNF for Children May 2022 Update

This update contains 5 significant changes and 1 dose change.

Significant Changes:
• Amiodarone hydrochloride (Cordarone X®): reminder of risks of treatment and need for patient monitoring and supervision [MHRA/CHM advice].
• COVID-19: updated guidance.
• Levetiracetam: addition of dosing for convulsive status epilepticus in children.
• Metformin hydrochloride: study shows no safety concerns in pregnancy [MHRA/CHM advice].
• Potassium permanganate: inadvertent oral administration of potassium permanganate [National Patient Safety Alert advice].

Dose change:
• Remdesivir [update to indications and dosing].

For further details on changes in the BNFC click on https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

11 Apr
British National Formulary for Children logo
BNF for Children April 2022 Update

This update contains 8 significant changes, 3 dose changes, 1 new preparation, and 1 deleted preparation.

Significant Changes:
• Chlorhexidine [primary therapeutic area changed to genito-urinary system, secondary therapeutic area changed to oropharynx].
• Chloroquine: increased risk of cardiovascular events when used with macrolide antibiotics; reminder of psychiatric reactions [MHRA/CHM advice].
• COVID-19 vaccines: updated guidance in-line with UK Health Security Agency recommendations.
• Hydroxychloroquine sulfate: increased risk of cardiovascular events when used with macrolide antibiotics; reminder of psychiatric reactions [MHRA/CHM advice].
• Immunisation schedule: updated guidance in-line with UK Health Security Agency recommendations.
• Ivacaftor: Ivacaftor, tezacaftor, elexacaftor (Kaftrio®▼) in combination with ivacaftor (Kalydeco®): risk of serious liver injury; updated advice on liver function testing [MHRA/CHM advice].
• Remdesivir: reporting to the UK COVID-19 Antivirals Pregnancy Registry [MHRA/CHM advice].
• Smoking cessation: updated guidance on management.

Dose Changes:
• Eltrombopag [addition of Southeast Asian ethnicity to dosing for treatment of chronic idiopathic thrombocytopenic purpura].
• Etanercept [update to dosing].
• Hepatitis B immunoglobulin [update to dosing in prophylaxis against hepatitis B infection from birth to 4 years old, and dosing in prevention of transmitted infection at birth].

New Preparation:
Vaxelis® [diphtheria with tetanus, pertussis, hepatitis B, poliomyelitis and haemophilus influenzae type b vaccine]

Deleted Preparation:
Synflorix® [pneumococcal polysaccharide conjugate vaccine (adsorbed)]

For further details on changes in the BNFC click on https://www.medicinescomplete.com/#/content/bnfc/PHP107699?hspl=changes

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